This drove highlights our near downloaded* jail cell and molecular papers published in 2019. Featuring authors from effectually the world, these papers feature valuable research from an international community.
*Information obtained from SN Insights which is based on Digital Science'southward Dimensions.
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A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories
Andrei Eastward. Tarkhov,
Ramani Alla ⋯
Peter O. Fedichev
Commodity | Open Access | | Scientific Reports
Discovery of NV-5138, the first selective Brain mTORC1 activator
Shomit Sengupta,
Emilie Giaime ⋯
Eddine Saiah
Article | Open Access | | Scientific Reports
Rapamycin modulates tissue aging and lifespan independently of the gut microbiota in Drosophila
Joseph M. Schinaman,
Anil Rana ⋯
David W. Walker
Article | Open Admission | | Scientific Reports
Single-cell transcriptome analysis identifies distinct cell types and niche signaling in a primary gastric organoid model
Jiamin Chen,
Billy T. Lau ⋯
Hanlee P. Ji
Article | Open Admission | | Scientific Reports
High sensitivity detection of extracellular vesicles immune-captured from urine by conventional menses cytometry
Carmen Campos-Silva,
Henar Suárez ⋯
Mar Valés-Gómez
Article | Open up Access | | Scientific Reports
Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule
Sabrina Chriett,
Arkadiusz Dąbek ⋯
Luciano Pirola
Commodity | Open Access | | Scientific Reports
Generation of complex human being organoid models including vascular networks past incorporation of mesodermal progenitor cells
Philipp Wörsdörfer,
Nahide Dalda ⋯
Süleyman Ergün
Article | Open up Access | | Scientific Reports
Generation of fully functional hepatocyte-like organoids from human being induced pluripotent stem cells mixed with Endothelial Cells
Giuseppe Pettinato,
Sylvain Lehoux ⋯
Robert A. Fisher
Commodity | Open up Admission | | Scientific Reports
The office of glycolysis and mitochondrial respiration in the formation and functioning of endothelial tip cells during angiogenesis
Bahar Yetkin-Arik,
Ilse Chiliad. C. Vogels ⋯
Reinier O. Schlingemann
Commodity | Open Access | | Scientific Reports
Combined quantification of intracellular (phospho-)proteins and transcriptomics from fixed single cells
Jan. P. Gerlach,
Jessie A. Chiliad. van Buggenum ⋯
Klaas Due west. Mulder
Article | Open Access | | Scientific Reports
Stalk jail cell exosomes inhibit angiogenesis and tumor growth of oral squamous prison cell carcinoma
Leonie Rosenberger,
Marcelo Ezquer ⋯
Francisca Alcayaga-Miranda
Article | Open Access | | Scientific Reports
Live-cell STED nanoscopy of mitochondrial cristae
Till Stephan,
Axel Roesch ⋯
Stefan Jakobs
Article | Open Admission | | Scientific Reports
Man adipose stromal-vascular fraction self-organizes to grade vascularized adipose tissue in 3D cultures
Sandra Muller,
Isabelle Ader ⋯
Frédéric Deschaseaux
Commodity | Open up Access | | Scientific Reports
Assembly of Man Stem Jail cell-Derived Cortical Spheroids and Vascular Spheroids to Model iii-D Encephalon-like Tissues
Liqing Song,
Xuegang Yuan ⋯
Yan Li
Commodity | Open Access | | Scientific Reports
Cancer cell migration on elongate protrusions of fibroblasts in collagen matrix
Kaoru Miyazaki,
Jun Oyanagi ⋯
Yohei Miyagi
Commodity | Open up Access | | Scientific Reports
Behaviors of Glioblastoma Cells in in Vitro Microenvironments
Wenwen Diao,
Xuezhi Tong ⋯
Zhong-Can Ou-Yang
Article | Open Admission | | Scientific Reports
Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy
Sijie Tan,
Chye Yun Yu ⋯
Esther Wong
Article | Open Access | | Scientific Reports
Self-organized intestinal epithelial monolayers in catacomb and villus-like domains show effective barrier function
Gizem Altay,
Enara Larrañaga ⋯
Elena Martínez
Article | Open Admission | | Scientific Reports
Mitochondria transfer from mesenchymal stalk cells structurally and functionally repairs renal proximal tubular epithelial cells in diabetic nephropathy in vivo
Naoto Konari,
Kanna Nagaishi ⋯
Mineko Fujimiya
Article | Open up Access | | Scientific Reports
A Novel Lactate Dehydrogenase Inhibitor, 1-(Phenylseleno)-iv-(Trifluoromethyl) Benzene, Suppresses Tumor Growth through Apoptotic Jail cell Decease
Eun-Yeong Kim,
Tae-Wook Chung ⋯
Ki-Tae Ha
Article | Open Access | | Scientific Reports
Autofluorescence is a Reliable in vitro Marker of Cellular Senescence in Human Mesenchymal Stromal Cells
Alessandro Bertolo,
Martin Baur ⋯
Jivko Stoyanov
Article | Open Access | | Scientific Reports
Metformin prevents prison cell tumorigenesis through autophagy-related prison cell death
Mauro De Santi,
Giulia Baldelli ⋯
Giorgio Brandi
Article | Open Access | | Scientific Reports
Transcriptome Assay of Long-lived Drosophila melanogaster E(z) Mutants Sheds Light on the Molecular Mechanisms of Longevity
Alexey A. Moskalev,
Mikhail V. Shaposhnikov ⋯
Anna V. Kudryavtseva
Article | Open Access | | Scientific Reports
OrgaQuant: Man Intestinal Organoid Localization and Quantification Using Deep Convolutional Neural Networks
Timothy Kassis,
Victor Hernandez-Gordillo ⋯
Linda Chiliad. Griffith
Article | Open Access | | Scientific Reports
Thermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice
Comparative Transcriptome and Methylome Analysis in Human being Skeletal Muscle Anabolism, Hypertrophy and Epigenetic Memory
Daniel C. Turner,
Robert A. Seaborne &
Adam P. Sharples
Article | Open Admission | | Scientific Reports
Traction force microscopy with optimized regularization and automated Bayesian parameter selection for comparing cells
Yunfei Huang,
Christoph Schell ⋯
Benedikt Sabass
Article | Open Access | | Scientific Reports
Wnt/β-catenin signaling pathway safeguards epigenetic stability and homeostasis of mouse embryonic stem cells
Ilda Theka,
Francesco Sottile ⋯
Maria Pia Cosma
Article | Open Access | | Scientific Reports
Pharmacological heave of DNA impairment response and repair by enhanced biogenesis of Deoxyribonucleic acid impairment response RNAs
Ubaldo Gioia,
Sofia Francia ⋯
Fabrizio d'Adda di Fagagna
Commodity | Open up Access | | Scientific Reports
Assessing metastatic potential of breast cancer cells based on EGFR dynamics
Yen-Liang Liu,
Chao-Kai Chou ⋯
Hsin-Chih Yeh
Article | Open Access | | Scientific Reports
Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation procedure and defects in mitochondrial respiration
Chowdhury S. Abdullah,
Shafiul Alam ⋯
Md. Shenuarin Bhuiyan
Article | Open Access | | Scientific Reports
Synchrony and asynchrony betwixt an epigenetic clock and developmental timing
Akina Hoshino,
Steve Horvath ⋯
Thomas A. Reh
Commodity | Open Access | | Scientific Reports
LC3-positive structures are prominent in autophagy-deficient cells
Gautam Runwal,
Eleanna Stamatakou ⋯
David C. Rubinsztein
Commodity | Open up Access | | Scientific Reports
MITF has a key role in regulating starvation-induced autophagy in melanoma
Katrin Möller,
Sara Sigurbjornsdottir ⋯
Margret H. Ogmundsdottir
Article | Open up Access | | Scientific Reports
A transgenic inducible GFP extracellular-vesicle reporter (TIGER) mouse illuminates neonatal cortical astrocytes every bit a source of immunomodulatory extracellular vesicles
Victoria Northward. Neckles,
Mary C. Morton ⋯
David M. Feliciano
Commodity | Open Admission | | Scientific Reports
Clostridium ramosum regulates enterochromaffin jail cell development and serotonin release
Ana D. Mandić,
Anni Woting ⋯
Michael Blaut
Commodity | Open Access | | Scientific Reports
Robust and efficient knock-in in embryonic stem cells and early-phase embryos of the common marmoset using the CRISPR-Cas9 system
Sho Yoshimatsu,
Junko Okahara ⋯
Hideyuki Okano
Commodity | Open Access | | Scientific Reports
Automated Sectionalisation of Fluorescence Microscopy Images for 3D Cell Detection in human-derived Cardiospheres
Massimo Salvi,
Umberto Morbiducci ⋯
Filippo Molinari
Article | Open Admission | | Scientific Reports
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells
Longfei Gao,
Shichao Huang ⋯
Gang Pei
Article | Open Access | | Scientific Reports
Cell cycle dynamics of mouse embryonic stalk cells in the ground state and during transition to formative pluripotency
Ariel Waisman,
Federico Sevlever ⋯
Alejandra S. Guberman
Article | Open up Access | | Scientific Reports
CRISPR/Cas9-mediated generation of a tyrosine hydroxylase reporter iPSC line for live imaging and isolation of dopaminergic neurons
Carles Calatayud,
Giulia Carola ⋯
Antonella Consiglio
Article | Open up Access | | Scientific Reports
Consecration of homo pluripotent stem cells into kidney tissues by synthetic mRNAs encoding transcription factors
Ken Hiratsuka,
Toshiaki Monkawa ⋯
Minoru S. H. Ko
Commodity | Open Admission | | Scientific Reports
Extracellular matrix remodelling induced past alternating electrical and mechanical stimulations increases the contraction of engineered skeletal muscle tissues
Hyeonyu Kim,
Min-Cheol Kim &
H. Harry Asada
Commodity | Open Access | | Scientific Reports
Src in endosomal membranes promotes exosome secretion and tumor progression
Tomoya Hikita,
Atsushi Kuwahara ⋯
Chitose Oneyama
Article | Open Access | | Scientific Reports
Transcriptomic analysis of 3D Cardiac Differentiation of Human Induced Pluripotent Stem Cells Reveals Faster Cardiomyocyte Maturation Compared to 2D Civilization
Mariana A. Branco,
João P. Cotovio ⋯
Maria Margarida Diogo
Article | Open up Admission | | Scientific Reports
Effect of cell civilization density on dental pulp-derived mesenchymal stem cells with reference to osteogenic differentiation
Sonoko Noda,
Nobuyuki Kawashima ⋯
Takashi Okiji
Commodity | Open Admission | | Scientific Reports
Homo skeletal muscle macrophages increase following cycle training and are associated with adaptations that may facilitate growth
R. Grace Walton,
Kate Kosmac ⋯
Charlotte A. Peterson
Commodity | Open Access | | Scientific Reports
MTrack: Automated Detection, Tracking, and Analysis of Dynamic Microtubules
Varun Kapoor,
William Chiliad. Hirst ⋯
Simone Reber
Article | Open Access | | Scientific Reports
Metabolomic Assay of Skeletal Muscle in Aged Mice
Ran Uchitomi,
Yukino Hatazawa ⋯
Yasutomi Kamei
Article | Open Access | | Scientific Reports
51-75
Pheno-seq – linking visual features and factor expression in 3D jail cell culture systems
Stephan M. Tirier,
Jeongbin Park ⋯
Christian Conrad
Article | Open Access | | Scientific Reports
Spatial Regulation of Mitochondrial Heterogeneity by Stromal Solitude in Micropatterned Tumor Models
Hydari Masuma Begum,
Hoang P. Ta ⋯
Keyue Shen
Article | Open Admission | | Scientific Reports
Membrane phospholipid amending causes chronic ER stress through early degradation of homeostatic ER-resident proteins
Peter Shyu Jr.,
Benjamin S. H. Ng ⋯
Guillaume Thibault
Commodity | Open Access | | Scientific Reports
E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca2+ Store Replenishment
Fei Kang,
Mengxuan Zhou ⋯
Liangyi Chen
Article | Open Admission | | Scientific Reports
Human mesenchymal stem cell sheets in xeno-costless media for possible allogenic applications
Kyungsook Kim,
Sophia Bou-Ghannam ⋯
Teruo Okano
Article | Open Access | | Scientific Reports
Single organelle analysis to characterize mitochondrial office and crosstalk during viral infection
Annika Schneider,
Sandra Kurz ⋯
Dirk Wohlleber
Commodity | Open Access | | Scientific Reports
Hypergravity and microgravity exhibited reversal furnishings on the bone and muscle mass in mice
Tsukasa Tominari,
Ryota Ichimaru ⋯
Masaki Inada
Article | Open up Access | | Scientific Reports
Development of a quantitative method to measure EV uptake
Víctor Toribio,
Sara Morales ⋯
María Yáñez-Mó
Article | Open Access | | Scientific Reports
Normalization strategies differently touch circulating miRNA profile associated with the training status
Martina Faraldi,
Marta Gomarasca ⋯
Giovanni Lombardi
Commodity | Open Access | | Scientific Reports
The nuclear interactome of DYRK1A reveals a functional role in Deoxyribonucleic acid harm repair
Steven Due east. Guard,
Zachary C. Poss ⋯
William M. Old
Article | Open Access | | Scientific Reports
CXCL4/PF4 is a predictive biomarker of cardiac differentiation potential of human induced pluripotent stalk cells
Fumiya Ohashi,
Shigeru Miyagawa ⋯
Yoji Sato
Article | Open Admission | | Scientific Reports
Loftier-Throughput, Time-Resolved Mechanical Phenotyping of Prostate Cancer Cells
Yuri Belotti,
Serenella Tolomeo ⋯
David McGloin
Article | Open Access | | Scientific Reports
Brain-stiffness-mimicking tilapia collagen gel promotes the induction of dorsal cortical neurons from human being pluripotent stem cells
Misato Iwashita,
Hatsumi Ohta ⋯
Yoichi Kosodo
Commodity | Open up Access | | Scientific Reports
Nano-mechanical mapping of interdependent cell and ECM mechanics past AFM strength spectroscopy
Prem Kumar Viji Babu,
Carmela Rianna ⋯
Manfred Radmacher
Article | Open Access | | Scientific Reports
Considerations for loftier-yield, high-throughput jail cell enrichment: fluorescence versus magnetic sorting
Bryan A. Sutermaster &
Eric M. Darling
Article | Open up Admission | | Scientific Reports
CRISPR knockout screen implicates three genes in lysosome office
Guy M. Lenk,
Young Due north. Park ⋯
Jacob O. Kitzman
Article | Open Access | | Scientific Reports
Host-directed kinase inhibitors act as novel therapies against intracellular Staphylococcus aureus
Natalia Bravo-Santano,
Helen Stölting ⋯
Michal Letek
Article | Open Admission | | Scientific Reports
Methylome and transcriptome maps of human being visceral and subcutaneous adipocytes reveal fundamental epigenetic differences at developmental genes
Stephen T. Bradford,
Shalima Due south. Nair ⋯
Susan J. Clark
Article | Open Access | | Scientific Reports
Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts
Zoe E. Gillespie,
Chenxuan Wang ⋯
Christopher H. Eskiw
Article | Open Admission | | Scientific Reports
Hair-follicle-associated pluripotent stalk cells derived from cryopreserved intact human pilus follicles sustain multilineage differentiation potential
Koya Obara,
Natsuko Tohgi ⋯
Yasuyuki Amoh
Article | Open Admission | | Scientific Reports
Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease
Jeongmin Lee,
Soo Jin Kwon ⋯
Duk 50. Na
Commodity | Open Access | | Scientific Reports
Colorectal cancer cells respond differentially to autophagy inhibition in vivo
Annie Lauzier,
Josiann Normandeau-Guimond ⋯
Steve Jean
Article | Open up Admission | | Scientific Reports
3D cell civilization stimulates the secretion of in vivo like extracellular vesicles
Sirisha Thippabhotla,
Cuncong Zhong &
Mei He
Commodity | Open up Access | | Scientific Reports
A sensitive and simple targeted proteomics approach to quantify transcription gene and membrane proteins of the unfolded protein response pathway in glioblastoma cells
Chi D. 50. Nguyen,
Sebastian Malchow ⋯
Robert Ahrends
Article | Open Access | | Scientific Reports
Tumorigenicity assay essential for facilitating condom studies of hiPSC-derived cardiomyocytes for clinical application
Emiko Ito,
Shigeru Miyagawa ⋯
Yoshiki Sawa
Commodity | Open up Access | | Scientific Reports
76-100
Jail cell population residuum of cardiovascular spheroids derived from human induced pluripotent stalk cells
Yuanwei Yan,
Julie Bejoy ⋯
Yan Li
Article | Open Access | | Scientific Reports
A rapid in vitro methodology for simultaneous target discovery and antibody generation confronting functional cell subpopulations
Allison M. L. Nixon,
Alejandro Duque ⋯
Jason Moffat
Article | Open Access | | Scientific Reports
Conversion of human and mouse fibroblasts into lung-like epithelial cells
Amy P. Wong,
Sharareh Shojaie ⋯
Janet Rossant
Commodity | Open Access | | Scientific Reports
A subset of topologically associating domains fold into mesoscale core-periphery networks
Harvey Huang,
Sunnia T. Chen ⋯
Jennifer East. Phillips-Cremins
Article | Open up Admission | | Scientific Reports
Unbiased peptoid combinatorial cell screen identifies plectin protein every bit a potential biomarker for lung cancer stalk cells
Aaron C. Raymond,
Boning Gao ⋯
D. Gomika Udugamasooriya
Article | Open Access | | Scientific Reports
The Regenerative Potential of Amniotic Fluid Stem Cell Extracellular Vesicles: Lessons Learned by Comparing Different Isolation Techniques
Lina Antounians,
Areti Tzanetakis ⋯
Augusto Zani
Article | Open Access | | Scientific Reports
Extensive reprogramming of the nascent transcriptome during iPSC to hepatocyte differentiation
Leena E. Viiri,
Tommi Rantapero ⋯
Katriina Aalto-Setälä
Commodity | Open Admission | | Scientific Reports
Quantitative phase imaging reveals matrix stiffness-dependent growth and migration of cancer cells
Yanfen Li,
Michael J. Fanous ⋯
Gabriel Popescu
Commodity | Open up Access | | Scientific Reports
Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice
Biju Joseph,
Guilherme Shimojo ⋯
Luis Ulloa
Article | Open up Access | | Scientific Reports
GRSF1 is an historic period-related regulator of senescence
Su-Jeong Kim,
Maria Chun ⋯
Pinchas Cohen
Article | Open Admission | | Scientific Reports
Automated real-fourth dimension monitoring of human pluripotent stem cell aggregation in stirred tank reactors
Ivo Schwedhelm,
Daniela Zdzieblo ⋯
Jan Hansmann
Commodity | Open up Access | | Scientific Reports
Membrane insertion and secretion of the Engrailed-2 (EN2) transcription factor by prostate cancer cells may induce antiviral activity in the stroma
Natasha Punia,
Monika Primon ⋯
Richard Morgan
Commodity | Open Access | | Scientific Reports
Association of Aggresomes with Survival Outcomes in Pediatric Medulloblastoma
Maha Yehia,
Hala Taha ⋯
Shahenda El-Naggar
Commodity | Open Access | | Scientific Reports
3-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle
Valentina Baena &
Marking Terasaki
Commodity | Open Access | | Scientific Reports
Primary neurons tin enter Grand-stage
Chaska C. Walton,
Wei Zhang ⋯
José M. Frade
Article | Open up Access | | Scientific Reports
In utero infection of Zika virus leads to abnormal fundamental nervous arrangement development in mice
Wei Zhang,
Yong Wah Tan ⋯
Li Zeng
Commodity | Open Access | | Scientific Reports
Live-cell imaging of subcellular structures for quantitative evaluation of pluripotent stem cells
Ken Nishimura,
Hiroshi Ishiwata ⋯
Koji Hisatake
Article | Open up Access | | Scientific Reports
Platelet lysate outperforms FCS and human serum for co-culture of chief human macrophages and hMSCs
Tina Tylek,
Tatjana Schilling ⋯
Jürgen Groll
Article | Open Admission | | Scientific Reports
Highly interacting regions of the human genome are enriched with enhancers and bound by DNA repair proteins
Haitham Sobhy,
Rajendra Kumar ⋯
Per Stenberg
Commodity | Open Access | | Scientific Reports
Widespread PERK-dependent repression of ER targets in response to ER stress
Nir Gonen,
Niv Sabath ⋯
Reut Shalgi
Article | Open Admission | | Scientific Reports
Maintenance of MYC expression promotes de novo resistance to BET bromodomain inhibition in castration-resistant prostate cancer
Daniel J. Coleman,
Lina Gao ⋯
Joshi J. Alumkal
Article | Open Access | | Scientific Reports
Functional Screening Identifies MicroRNAs as Multi-Cellular Regulators of Heart Failure
Robin Verjans,
Wouter J. A. Derks ⋯
Stephane Heymans
Article | Open Access | | Scientific Reports
A novel ex vivo tumor system identifies Src-mediated invasion and metastasis in mesenchymal tumor cells in non-pocket-size jail cell lung cancer
Aparna Padhye,
Christin Ungewiss ⋯
Don L. Gibbons
Article | Open Access | | Scientific Reports
Endothelial tip cells in vitro are less glycolytic and have a more than flexible response to metabolic stress than non-tip cells
B. Yetkin-Arik,
I. M. C. Vogels ⋯
R. O. Schlingemann
Article | Open Access | | Scientific Reports
Master lung cancer samples cultured under microenvironment-mimetic conditions enrich for mesenchymal stem-like cells that promote metastasis
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